Ontology highlight
ABSTRACT:
SUBMITTER: Schlegelmilch K
PROVIDER: S-EPMC3237196 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Schlegelmilch Karin K Mohseni Morvarid M Kirak Oktay O Pruszak Jan J Rodriguez J Renato JR Zhou Dawang D Kreger Bridget T BT Vasioukhin Valera V Avruch Joseph J Brummelkamp Thijn R TR Camargo Fernando D FD
Cell 20110301 5
During development and regeneration, proliferation of tissue-specific stem cells is tightly controlled to produce organs of a predetermined size. The molecular determinants of this process remain poorly understood. Here, we investigate the function of Yap1, the transcriptional effector of the Hippo signaling pathway, in skin biology. Using gain- and loss-of-function studies, we show that Yap1 is a critical modulator of epidermal stem cell proliferation and tissue expansion. Yap1 mediates this ef ...[more]