Ontology highlight
ABSTRACT:
SUBMITTER: Taylor WR
PROVIDER: S-EPMC3237328 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
PloS one 20111205 12
Residue contact predictions were calculated based on the mutual information observed between pairs of positions in large multiple protein sequence alignments. Where previously only the statistical properties of these data have been considered important, we introduce new measures to impose constraints that make the contact map more consistent with a three dimensional structure. These included global (bulk) properties and local secondary structure properties. The latter allowed the contact constra ...[more]