Defining pheromone-receptor signaling in Candida albicans and related asexual Candida species.
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ABSTRACT:
SUBMITTER: Lin CH
PROVIDER: S-EPMC3237633 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
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Defining pheromone-receptor signaling in Candida albicans and related asexual Candida species.
Lin Ching-Hsuan CH Choi Anthony A Bennett Richard J RJ
Molecular biology of the cell 20111012 24
Candida albicans is an important human fungal pathogen in which sexual reproduction is under the control of the novel white-opaque switch. Opaque cells are the mating-competent form, whereas white cells do not mate but can still respond to pheromones, resulting in biofilm formation. In this study, we first define the domains of the α-pheromone receptor Ste2 that are necessary for signaling in both white and opaque forms. Both cell states require the IC loop 3 (IC3) and the C-terminal tail of Ste ...[more]
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