Ontology highlight
ABSTRACT:
SUBMITTER: Gorboulev V
PROVIDER: S-EPMC3237647 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Gorboulev Valentin V Schürmann Annette A Vallon Volker V Kipp Helmut H Jaschke Alexander A Klessen Dirk D Friedrich Alexandra A Scherneck Stephan S Rieg Timo T Cunard Robyn R Veyhl-Wichmann Maike M Srinivasan Aruna A Balen Daniela D Breljak Davorka D Rexhepaj Rexhep R Parker Helen E HE Gribble Fiona M FM Reimann Frank F Lang Florian F Wiese Stefan S Sabolic Ivan I Sendtner Michael M Koepsell Hermann H
Diabetes 20111128 1
To clarify the physiological role of Na(+)-D-glucose cotransporter SGLT1 in small intestine and kidney, Sglt1(-/-) mice were generated and characterized phenotypically. After gavage of d-glucose, small intestinal glucose absorption across the brush-border membrane (BBM) via SGLT1 and GLUT2 were analyzed. Glucose-induced secretion of insulinotropic hormone (GIP) and glucagon-like peptide 1 (GLP-1) in wild-type and Sglt1(-/-) mice were compared. The impact of SGLT1 on renal glucose handling was in ...[more]