Polymorphisms of XPG/ERCC5 and risk of squamous cell carcinoma of the head and neck.

ABSTRACT:

Objectives

Xeroderma pigmentosum group G (XPG) protein is essential for the nucleotide excision repair system, and genetic variations in XPG/ERCC5 that affect DNA repair capacity may contribute to the risk of tobacco-induced cancers, including squamous cell carcinoma of the head and neck (SCCHN). We investigated the association between XPG/ERCC5 polymorphisms and risk of SCCHN.

Methods

We genotyped 12 tagging and potentially functional single nucleotide polymorphisms (SNPs) of XPG/ERCC5 in a case-control study of 1059 non-Hispanic white patients with SCCHN and 1066 cancer-free age- and sex-matched controls, and evaluated their associations with the risk of SCCHN.

Results

Multivariate logistic regression showed that only an intronic tagging SNP (rs4150351A/C) of XPG/ER

SUBMITTER: Ma H 

PROVIDER: S-EPMC3237901 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature