Ontology highlight
ABSTRACT:
SUBMITTER: Zhu Q
PROVIDER: S-EPMC3240576 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Zhu Quan Q Pao Gerald M GM Huynh Alexis M AM Suh Hoonkyo H Tonnu Nina N Nederlof Petra M PM Gage Fred H FH Verma Inder M IM
Nature 20110907 7363
Mutations in the tumour suppressor gene BRCA1 lead to breast and/or ovarian cancer. Here we show that loss of Brca1 in mice results in transcriptional de-repression of the tandemly repeated satellite DNA. Brca1 deficiency is accompanied by a reduction of condensed DNA regions in the genome and loss of ubiquitylation of histone H2A at satellite repeats. BRCA1 binds to satellite DNA regions and ubiquitylates H2A in vivo. Ectopic expression of H2A fused to ubiquitin reverses the effects of BRCA1 lo ...[more]