Ancestral components of admixed genomes in a Mexican cohort.

ABSTRACT: For most of the world, human genome structure at a population level is shaped by interplay between ancient geographic isolation and more recent demographic shifts, factors that are captured by the concepts of biogeographic ancestry and admixture, respectively. The ancestry of non-admixed individuals can often be traced to a specific population in a precise region, but current approaches for studying admixed individuals generally yield coarse information in which genome ancestry proportions are identified according to continent of origin. Here we introduce a new analytic strategy for this problem that allows fine-grained characterization of admixed individuals with respect to both geographic and genomic coordinates. Ancestry segments from different continents, identified with a probabilisti

SUBMITTER: Johnson NA 

PROVIDER: S-EPMC3240599 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature