Ontology highlight
ABSTRACT:
SUBMITTER: Schmitt AM
PROVIDER: S-EPMC3240852 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Schmitt Adam M AM Crawley Clayton D CD Kang Shijune S Raleigh David R DR Yu Xiaohong X Wahlstrom Joshua S JS Voce David J DJ Darga Thomas E TE Weichselbaum Ralph R RR Yamini Bakhtiar B
Molecular cell 20111201 5
The functional significance of the signaling pathway induced by O(6)-methylguanine (O(6)-MeG) lesions is poorly understood. Here, we identify the p50 subunit of NF-κB as a central target in the response to O(6)-MeG and demonstrate that p50 is required for S(N)1-methylator-induced cytotoxicity. In response to S(N)1-methylation, p50 facilitates the inhibition of NF-κB-regulated antiapoptotic gene expression. Inhibition of NF-κB activity is noted to be an S phase-specific phenomenon that requires t ...[more]