Ontology highlight
ABSTRACT:
SUBMITTER: Wan L
PROVIDER: S-EPMC3240853 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Wan Lixin L Zou Weiguo W Gao Daming D Inuzuka Hiroyuki H Fukushima Hidefumi H Berg Anders H AH Drapp Rebecca R Shaik Shavali S Hu Dorothy D Lester Chantel C Eguren Manuel M Malumbres Marcos M Glimcher Laurie H LH Wei Wenyi W
Molecular cell 20111201 5
The APC/Cdh1 E3 ubiquitin ligase plays an essential role in both mitotic exit and G1/S transition by targeting key cell-cycle regulators for destruction. There is mounting evidence indicating that Cdh1 has other functions in addition to cell-cycle regulation. However, it remains unclear whether these additional functions depend on its E3 ligase activity. Here, we report that Cdh1, but not Cdc20, promotes the E3 ligase activity of Smurf1. This is mediated by disruption of an autoinhibitory Smurf1 ...[more]