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Handpicking epigenetic marks with PHD fingers.

ABSTRACT: Plant homeodomain (PHD) fingers have emerged as one of the largest families of epigenetic effectors capable of recognizing or 'reading' post-translational histone modifications and unmodified histone tails. These interactions are highly specific and can be modulated by the neighboring epigenetic marks and adjacent effectors. A few PHD fingers have recently been found to also associate with non-histone proteins. In this review, we detail the molecular mechanisms and biological outcomes of the histone and non-histone targeting by PHD fingers. We discuss the significance of crosstalk between the histone modifications and consequences of combinatorial readout for selective recruitment of the PHD finger-containing components of chromatin remodeling and transcriptional complexes.

SUBMITTER: Musselman CA

PROVIDER: S-EPMC3241642 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

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Handpicking epigenetic marks with PHD fingers.

Musselman Catherine A CA Kutateladze Tatiana G TG

Nucleic acids research 20110803 21

Plant homeodomain (PHD) fingers have emerged as one of the largest families of epigenetic effectors capable of recognizing or 'reading' post-translational histone modifications and unmodified histone tails. These interactions are highly specific and can be modulated by the neighboring epigenetic marks and adjacent effectors. A few PHD fingers have recently been found to also associate with non-histone proteins. In this review, we detail the molecular mechanisms and biological outcomes of the his ...[more]

PMID: 21813457

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