Ontology highlight
ABSTRACT:
SUBMITTER: Lu X
PROVIDER: S-EPMC3241854 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Lu Xin X Mu Euphemia E Wei Yong Y Riethdorf Sabine S Yang Qifeng Q Yuan Min M Yan Jun J Hua Yuling Y Tiede Benjamin J BJ Lu Xuemin X Haffty Bruce G BG Pantel Klaus K Massagué Joan J Kang Yibin Y
Cancer cell 20111201 6
Breast cancer patients often develop locoregional or distant recurrence years after mastectomy. Understanding the mechanism of metastatic recurrence after dormancy is crucial for improving the cure rate for breast cancer. Here, we characterize a bone metastasis dormancy model to show that aberrant expression of vascular cell adhesion molecule 1 (VCAM-1), in part dependent on the activity of the NF-κB pathway, promotes the transition from indolent micrometastasis to overt metastasis. By interacti ...[more]