Ontology highlight
ABSTRACT:
SUBMITTER: Purington LC
PROVIDER: S-EPMC3241856 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Purington Lauren C LC Sobczyk-Kojiro Katarzyna K Pogozheva Irina D ID Traynor John R JR Mosberg Henry I HI
ACS chemical biology 20111011 12
The development of tolerance to and dependence on opioid analgesics greatly reduces their long-term usefulness. Previous studies have demonstrated that co-administration of a μ-opioid receptor (MOR) agonist and δ-opioid receptor (DOR) antagonist can decrease MOR agonist-induced tolerance and dependence development after chronic exposure. Clinically, a single ligand displaying multiple efficacies (e.g., MOR agonism concurrently with DOR antagonism) would be of increased value over two drugs admin ...[more]