Ontology highlight
ABSTRACT:
SUBMITTER: Sheehy SH
PROVIDER: S-EPMC3242658 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Sheehy Susanne H SH Duncan Christopher J A CJ Elias Sean C SC Collins Katharine A KA Ewer Katie J KJ Spencer Alexandra J AJ Williams Andrew R AR Halstead Fenella D FD Moretz Samuel E SE Miura Kazutoyo K Epp Christian C Dicks Matthew D J MD Poulton Ian D ID Lawrie Alison M AM Berrie Eleanor E Moyle Sarah S Long Carole A CA Colloca Stefano S Cortese Riccardo R Gilbert Sarah C SC Nicosia Alfredo A Hill Adrian V S AV Draper Simon J SJ
Molecular therapy : the journal of the American Society of Gene Therapy 20110823 12
Efficacy trials of antibody-inducing protein-in-adjuvant vaccines targeting the blood-stage Plasmodium falciparum malaria parasite have so far shown disappointing results. The induction of cell-mediated responses in conjunction with antibody responses is thought to be one alternative strategy that could achieve protective efficacy in humans. Here, we prepared chimpanzee adenovirus 63 (ChAd63) and modified vaccinia virus Ankara (MVA) replication-deficient vectors encoding the well-studied P. falc ...[more]