Data-independent proteomic screen identifies novel tamoxifen agonist that mediates drug resistance.
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ABSTRACT:
SUBMITTER: Hengel SM
PROVIDER: S-EPMC3242698 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Publications
Data-independent proteomic screen identifies novel tamoxifen agonist that mediates drug resistance.
Hengel Shawna Mae SM Murray Euan E Langdon Simon S Hayward Larry L O'Donoghue Jean J Panchaud Alexandre A Hupp Ted T Goodlett David R DR
Journal of proteome research 20110921 10
A label-free quantitative variation of the recently developed data-independent shotgun proteomic method precursor acquisition independent from ion count (PAcIFIC) was used to identify novel proteins implicated in cancer progression and resistance. Specifically, this screen identified the pro-metastatic protein anterior gradient 2 (AGR2) as significantly up-regulated in tamoxifen-treated cells. Highlighting the need for direct proteome profiling methods like PAcIFIC, neither data-dependent gas-ph ...[more]
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