Ontology highlight
ABSTRACT:
SUBMITTER: Shi Y
PROVIDER: S-EPMC3242707 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Shi Yongjun Y Chen Wei W Jalal Diana D Li Zhibin Z Chen Wenfang W Mao Haiping H Yang Qiongqiong Q Johnson Richard J RJ Yu Xueqing X
Kidney & blood pressure research 20111123 3
<h4>Background</h4>Hyperuricemia is an independent risk factor for renal progression in IgA nephropathy (IgAN). However, no study has evaluated the effect of allopurinol on the clinical outcome in hyperuricemic IgAN.<h4>Methods</h4>First,a retrospective cohort study of 353 IgAN patients was conducted to explore the relationship between uric acid (UA) and the progression of renal disease over a mean period of 5 years. Then, 40 hyperuricemic IgAN patients were randomized to receive allopurinol (10 ...[more]