Ontology highlight
ABSTRACT:
SUBMITTER: Frith MC
PROVIDER: S-EPMC3242753 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
PloS one 20111219 12
Detection of sequences that are homologous, i.e. descended from a common ancestor, is a fundamental task in computational biology. This task is confounded by low-complexity tracts (such as atatatatatat), which arise frequently and independently, causing strong similarities that are not homologies. There has been much research on identifying low-complexity tracts, but little research on how to treat them during homology search. We propose to find homologies by aligning sequences with "gentle" mas ...[more]