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Regulatory gene network circuits underlying T cell development from multipotent progenitors.

ABSTRACT: Regulatory gene circuits enable stem and progenitor cells to detect and process developmental signals and make irreversible fate commitment decisions. To gain insight into the gene circuits underlying T cell fate decision making in progenitor cells, we generated an updated T-lymphocyte developmental gene regulatory network from genes and connections found in the literature. This reconstruction allowed us to identify candidate regulatory gene circuit elements underlying T cell fate decision making. Here, we examine the roles of these circuits in facilitating different aspects of the decision making process, and discuss experiments to further probe their structure and function.

SUBMITTER: Kueh HY

PROVIDER: S-EPMC3242926 | biostudies-literature | 2012 Jan-Feb

REPOSITORIES: biostudies-literature

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Regulatory gene network circuits underlying T cell development from multipotent progenitors.

Kueh Hao Yuan HY Rothenberg Ellen V EV

Wiley interdisciplinary reviews. Systems biology and medicine 20111004 1

Regulatory gene circuits enable stem and progenitor cells to detect and process developmental signals and make irreversible fate commitment decisions. To gain insight into the gene circuits underlying T cell fate decision making in progenitor cells, we generated an updated T-lymphocyte developmental gene regulatory network from genes and connections found in the literature. This reconstruction allowed us to identify candidate regulatory gene circuit elements underlying T cell fate decision makin ...[more]

PMID: 21976153

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Dataset Information

Regulatory gene network circuits underlying T cell development from multipotent progenitors.

Publications

Regulatory gene network circuits underlying T cell development from multipotent progenitors.

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