Ontology highlight
ABSTRACT:
SUBMITTER: Craig EA
PROVIDER: S-EPMC3242936 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Craig Evisabel A EA Spiegelman Vladimir S VS
Pigment cell & melanoma research 20111028 1
We previously reported that malignant melanomas express high levels of the mRNA binding protein coding region determinant binding protein (CRD-BP). This molecule is important for the activation of anti-apoptotic pathways, a mechanism often linked to insensitivity to therapeutics. However, it is not known whether CRD-BP plays a role in the resistance of melanomas to anti-cancer treatment. Here we demonstrate that knockdown of CRD-BP with a specific sh-RNA enhances the effect of dacarbazine, temoz ...[more]