Ontology highlight
ABSTRACT:
SUBMITTER: Liang HE
PROVIDER: S-EPMC3242938 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Liang Hong-Erh HE Reinhardt R Lee RL Bando Jennifer K JK Sullivan Brandon M BM Ho I-Cheng IC Locksley Richard M RM
Nature immunology 20111204 1
Interleukin 4 (IL-4) and IL-13 are critical for responses to parasitic helminthes. We used genetically engineered reporter mice to assess the temporal and spatial production of these cytokines in vivo. In lymph nodes, IL-4, but not IL-13, was made by follicular helper T cells (T(FH) cells). In contrast, tissue type 2 helper T cells (T(H)2 cells) produced both cytokines. There was also divergent production of IL-4 and IL-13 among cells of the innate immune system, whereby basophils produced IL-4, ...[more]