Evaluating de novo locus-disease discoveries in GWAS using the signal-to-noise ratio.
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ABSTRACT:
SUBMITTER: Jiang X
PROVIDER: S-EPMC3243170 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Evaluating de novo locus-disease discoveries in GWAS using the signal-to-noise ratio.
Jiang Xia X Barmada M Michael MM Becich Michael J MJ
AMIA ... Annual Symposium proceedings. AMIA Symposium 20111022
A genome-wide association study (GWAS) involves examining representative SNPs obtained using high throughput technologies. A GWAS data set can entail a million SNPs and may soon entail many millions. In a GWAS researchers often investigate the correlation of each SNP with a disease. With so many hypotheses, it is not straightforward how to interpret the results. Strategies include using the Bonferroni correction to determine the significance of a model and Bayesian methods. However, when we are ...[more]
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