Similarity-based disease risk assessment for personal genomes: proof of concept.
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ABSTRACT:
SUBMITTER: Woo JH
PROVIDER: S-EPMC3243222 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Similarity-based disease risk assessment for personal genomes: proof of concept.
Woo Jung Hoon JH Lai Albert M AM Chung Wendy K WK Weng Chunhua C
AMIA ... Annual Symposium proceedings. AMIA Symposium 20111022
The increasing availability of personal genome data has led to escalating needs by consumers to understand the implications of their gene sequences. At present, poorly integrated genetic knowledge has not met these needs. This proof-of-concept study proposes a similarity-based approach to assess the disease risk predisposition for personal genomes. We hypothesize that the semantic similarity between a personal genome and a disease can indicate the disease risks in the person. We developed a know ...[more]
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