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ABSTRACT:
SUBMITTER: Imagawa T
PROVIDER: S-EPMC3243531 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Imagawa Takahito T Tsurumura Toshiharu T Sugimoto Yasushi Y Aki Kenji K Ishidoh Kazumi K Kuramitsu Seiki S Tsuge Hideaki H
The Journal of biological chemistry 20111103 51
Free reduced flavins are involved in a variety of biological functions. They are generated from NAD(P)H by flavin reductase via co-factor flavin bound to the enzyme. Although recent findings on the structure and function of flavin reductase provide new information about co-factor FAD and substrate NAD, there have been no reports on the substrate flavin binding site. Here we report the structure of TTHA0420 from Thermus thermophilus HB8, which belongs to flavin reductase, and describe the dual bi ...[more]