Ontology highlight
ABSTRACT:
SUBMITTER: Nishimura I
PROVIDER: S-EPMC3243532 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Nishimura Ichiro I Chano Tokuhiro T Kita Hiroko H Matsusue Yoshitaka Y Okabe Hidetoshi H
The Journal of biological chemistry 20111102 51
RB1-inducible coiled-coil 1 (RB1CC1) functions in various processes, such as cell growth, differentiation, senescence, apoptosis, and autophagy. The conditional transgenic mice with cartilage-specific RB1CC1 excess that were used in the present study were made for the first time by the Cre-loxP system. Cartilage-specific RB1CC1 excess caused dwarfism in mice without causing obvious abnormalities in endochondral ossification and subsequent skeletal development from embryo to adult. In vitro and i ...[more]