Ontology highlight
ABSTRACT:
SUBMITTER: Biglione S
PROVIDER: S-EPMC3243562 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Biglione Sebastian S Tsytsykova Alla V AV Goldfeld Anne E AE
The Journal of biological chemistry 20111025 51
Regulation of TNF gene expression is cell type- and stimulus-specific. We have previously identified highly conserved noncoding regulatory elements within DNase I-hypersensitive sites (HSS) located 9 kb upstream (HSS-9) and 3 kb downstream (HSS+3) of the TNF gene, which play an important role in the transcriptional regulation of TNF in T cells. They act as enhancers and interact with the TNF promoter and with each other, generating a higher order chromatin structure. Here, we report a novel mono ...[more]