Ontology highlight
ABSTRACT:
SUBMITTER: Legate KR
PROVIDER: S-EPMC3243596 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Legate Kyle R KR Takahashi Seiichiro S Bonakdar Navid N Fabry Ben B Boettiger David D Zent Roy R Fässler Reinhard R
The EMBO journal 20111101 22
The 90-kDa isoform of the lipid kinase PIP kinase Type I γ (PIPKIγ) localizes to focal adhesions (FAs), where it provides a local source of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)). Although PtdIns(4,5)P(2) regulates the function of several FA-associated molecules, the role of the FA-specific pool of PtdIns(4,5)P(2) is not known. We report that the genetic ablation of PIPKIγ specifically from FAs results in defective integrin-mediated adhesion and force coupling. Adhesion defects ...[more]