Cardiac bidomain bath-loading effects during arrhythmias: interaction with anatomical heterogeneity.

ABSTRACT: Cardiac tissue is always surrounded by conducting fluid, both in vivo (blood) and in experimental preparations (Tyrode's solution), which acts to increase conduction velocity (CV) close to the tissue-fluid interface, inducing transmural wavefront curvature. Despite its potential importance, computer modeling studies focused on arrhythmia mechanisms have previously not accounted for these bath-loading effects. Here, we investigate the increase in CV and concomitant change in transmural wavefront profiles upon both propagation and arrhythmia dynamics within models of differing anatomical complexity. In simplified slab models, in absence of transmural fiber rotation, bath-loading induced transmural wavefront curvature dominates, significantly increasing arrhythmia complexity compared to no ba

SUBMITTER: Bishop MJ 

PROVIDER: S-EPMC3244060 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature