Autophagy proteins regulate the secretory component of osteoclastic bone resorption.
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ABSTRACT:
SUBMITTER: DeSelm CJ
PROVIDER: S-EPMC3244473 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Publications
Autophagy proteins regulate the secretory component of osteoclastic bone resorption.
DeSelm Carl J CJ Miller Brian C BC Zou Wei W Beatty Wandy L WL van Meel Eline E Takahata Yoshifumi Y Klumperman Judith J Tooze Sharon A SA Teitelbaum Steven L SL Virgin Herbert W HW
Developmental cell 20111104 5
Osteoclasts resorb bone via the ruffled border, whose complex folds are generated by secretory lysosome fusion with bone-apposed plasma membrane. Lysosomal fusion with the plasmalemma results in acidification of the resorptive microenvironment and release of CatK to digest the organic matrix of bone. The means by which secretory lysosomes are directed to fuse with the ruffled border are enigmatic. We show that proteins essential for autophagy, including Atg5, Atg7, Atg4B, and LC3, are important ...[more]
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