Ontology highlight
ABSTRACT:
SUBMITTER: Holtze M
PROVIDER: S-EPMC3244499 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Holtze Maria M Saetre Peter P Engberg Göran G Schwieler Lilly L Werge Thomas T Andreassen Ole A OA Hall Håkan H Terenius Lars L Agartz Ingrid I Jönsson Erik G EG Schalling Martin M Erhardt Sophie S
Journal of psychiatry & neuroscience : JPN 20120101 1
<h4>Background</h4>Patients with schizophrenia show increased brain and cerebrospinal fluid (CSF) concentrations of the endogenous N-methyl-D-aspartate receptor antagonist kynurenic acid (KYNA). This compound is an end-metabolite of the kynurenine pathway, and its formation indirectly depends on the activity of kynurenine 3-monooxygenase (KMO), the enzyme converting kynurenine to 3-hydroxykynurenine.<h4>Methods</h4>We analyzed the association between KMO gene polymorphisms and CSF concentrations ...[more]