Ontology highlight
ABSTRACT:
SUBMITTER: He Y
PROVIDER: S-EPMC3244655 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
He Yunlong Y Korboukh Ilia I Jin Jian J Huang Jing J
Acta biochimica et biophysica Sinica 20120101 1
During the last decade, we saw an explosion of studies investigating the role of lysine methylation/demethylation of histones and non-histone proteins, such as p53, NF-kappaB, and E2F1. These 'Ying-Yang' post-translational modifications are important to fine-tuning the activity of these proteins. Lysine methylation and demethylation are catalyzed by protein lysine methyltransferases (PKMTs) and protein lysine demethylases (PKDMs). PKMTs, PKDMs, and their substrates have been shown to play import ...[more]