Ontology highlight
ABSTRACT:
SUBMITTER: Prosperi JR
PROVIDER: S-EPMC3245255 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Prosperi Jenifer R JR Khramtsov Andrey I AI Khramtsova Galina F GF Goss Kathleen H KH
PloS one 20111222 12
The Adenomatous Polyposis Coli (APC) tumor suppressor gene is silenced by hypermethylation or mutated in up to 70% of human breast cancers. In mouse models, Apc mutation disrupts normal mammary development and predisposes to mammary tumor formation; however, the cooperation between APC and other mutations in breast tumorigenesis has not been studied. To test the hypothesis that loss of one copy of APC promotes oncogene-mediated mammary tumorigenesis, Apc(Min/+) mice were crossed with the mouse m ...[more]