Ontology highlight
ABSTRACT:
SUBMITTER: Lee YD
PROVIDER: S-EPMC3245869 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Lee Yang David YD Wang Jun J Stubbe Joanne J Elledge Stephen J SJ
Molecular cell 20081001 1
The control of dNTP concentrations is critical to the fidelity of DNA synthesis and repair. One level of regulation is through subcellular localization of ribonucleotide reductase. In Saccharomyces cerevisiae, the small subunit Rnr2-Rnr4 is nuclear, whereas the large subunit Rnr1 is cytoplasmic. In response to S phase or DNA damage, Rnr2-Rnr4 enters the cytoplasm to bind Rnr1, forming an active complex. We previously reported that Wtm1 anchors Rnr2-Rnr4 in the nucleus. Here, we identify DIF1, wh ...[more]