Ontology highlight
ABSTRACT:
SUBMITTER: Calvanese V
PROVIDER: S-EPMC3245917 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Calvanese Vincenzo V Fernández Agustín F AF Urdinguio Rocío G RG Suárez-Alvarez Beatriz B Mangas Cristina C Pérez-García Vicente V Bueno Clara C Montes Rosa R Ramos-Mejía Verónica V Martínez-Camblor Pablo P Martínez-Camblor Pablo P Ferrero Cecilia C Assenov Yassen Y Bock Christoph C Menendez Pablo P Carrera Ana Clara AC Lopez-Larrea Carlos C Fraga Mario F MF
Nucleic acids research 20110912 1
Global mechanisms defining the gene expression programs specific for hematopoiesis are still not fully understood. Here, we show that promoter DNA demethylation is associated with the activation of hematopoietic-specific genes. Using genome-wide promoter methylation arrays, we identified 694 hematopoietic-specific genes repressed by promoter DNA methylation in human embryonic stem cells and whose loss of methylation in hematopoietic can be associated with gene expression. The association between ...[more]