Ontology highlight
ABSTRACT:
SUBMITTER: Nejepinska J
PROVIDER: S-EPMC3245926 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Nejepinska Jana J Malik Radek R Filkowski Jody J Flemr Matyas M Filipowicz Witold W Svoboda Petr P
Nucleic acids research 20110908 1
Double-stranded RNA (dsRNA) can enter different pathways in mammalian cells, including sequence-specific RNA interference (RNAi), sequence-independent interferon (IFN) response and editing by adenosine deaminases. To study the routing of dsRNA to these pathways in vivo, we used transgenic mice ubiquitously expressing from a strong promoter, an mRNA with a long hairpin in its 3'-UTR. The expressed dsRNA neither caused any developmental defects nor activated the IFN response, which was inducible o ...[more]