Ontology highlight
ABSTRACT:
SUBMITTER: Horbinski C
PROVIDER: S-EPMC3246063 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Horbinski Craig C Nikiforova Marina N MN Hobbs Jonathan J Bortoluzzi Stephanie S Cieply Kathleen K Dacic Sanja S Hamilton Ronald L RL
Journal of neuropathology and experimental neurology 20120101 1
1p/19q codeletion is a favorable prognostic marker of oligodendrogliomas. Although fluorescence in situ hybridization (FISH) and microsatellite-based polymerase chain reaction (PCR) for loss of heterozygosity (LOH) are common methods to test for 1p/19q codeletion, it is unclear which test is better at prognostic stratification. This study analyzed outcomes of 111 oligodendrogliomas with both 1p/19q FISH and LOH done at the time of diagnosis. Overall concordance between the 2 assays was 81.1%. In ...[more]