NMDA receptors in dopaminergic neurons are crucial for habit learning.
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ABSTRACT:
SUBMITTER: Wang LP
PROVIDER: S-EPMC3246213 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Publications
NMDA receptors in dopaminergic neurons are crucial for habit learning.
Wang Lei Phillip LP Li Fei F Wang Dong D Xie Kun K Wang Deheng D Shen Xiaoming X Tsien Joe Z JZ
Neuron 20111201 6
Dopamine is crucial for habit learning. Activities of midbrain dopaminergic neurons are regulated by the cortical and subcortical signals among which glutamatergic afferents provide excitatory inputs. Cognitive implications of glutamatergic afferents in regulating and engaging dopamine signals during habit learning, however, remain unclear. Here, we show that mice with dopaminergic neuron-specific NMDAR1 deletion are impaired in a variety of habit-learning tasks, while normal in some other dopam ...[more]
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