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Intercepting bacterial indole signaling with flustramine derivatives.

ABSTRACT: Indole signaling is one of the putative universal signaling networks in bacteria. We have investigated the use of desformylflustrabromine (dFBr) derivatives for the inhibition of biofilm formation through modulation of the indole-signaling network in Escherichia coli and Staphylococcus aureus . We have found dFBr derivatives that are 10-1000 times more active than indole itself, demonstrating that the flustramine family of indolic natural products represent a privileged scaffold for the design of molecules to control pathogenic bacterial behavior.

SUBMITTER: Bunders CA

PROVIDER: S-EPMC3246311 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature

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Intercepting bacterial indole signaling with flustramine derivatives.

Bunders Cynthia A CA Minvielle Marine J MJ Worthington Roberta J RJ Ortiz Minoshka M Cavanagh John J Melander Christian C

Journal of the American Chemical Society 20111122 50

Indole signaling is one of the putative universal signaling networks in bacteria. We have investigated the use of desformylflustrabromine (dFBr) derivatives for the inhibition of biofilm formation through modulation of the indole-signaling network in Escherichia coli and Staphylococcus aureus . We have found dFBr derivatives that are 10-1000 times more active than indole itself, demonstrating that the flustramine family of indolic natural products represent a privileged scaffold for the desig ...[more]

PMID: 22091927

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