Ontology highlight
ABSTRACT:
SUBMITTER: Kim YM
PROVIDER: S-EPMC3246421 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Kim Young-Mee YM Pyo Hongryull H
DNA and cell biology 20110810 1
We investigated whether the combined treatment of 17-(allylamino)-17-demethoxygeldanamycin (17-AAG), an inhibitor of heat-shock protein 90 (hsp90), and celecoxib, an inhibitor of cyclooxygenase-2, can cooperatively enhance the radiosensitivity of various human cancer cells. Combined treatment with 17-AAG and celecoxib, at clinically relevant concentrations, cooperatively induced radiosensitization in all tested cancer cells, but not in normal cells. Cooperative radiosensitization by the drug com ...[more]