Ontology highlight
ABSTRACT:
SUBMITTER: Abedi-Ardekani B
PROVIDER: S-EPMC3246475 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Abedi-Ardekani Behnoush B Kamangar Farin F Sotoudeh Masoud M Villar Stephanie S Islami Farhad F Aghcheli Karim K Nasrollahzadeh Dariush D Taghavi Noushin N Dawsey Sanford M SM Abnet Christian C CC Hewitt Stephen M SM Fahimi Saman S Saidi Farrokh F Brennan Paul P Boffetta Paolo P Malekzadeh Reza R Hainaut Pierre P
PloS one 20111227 12
<h4>Background</h4>Golestan Province in northeastern Iran has one of the highest incidences of esophageal squamous cell carcinoma (ESCC) in the world with rates over 50 per 100,000 person-years in both sexes. We have analyzed TP53 mutation patterns in tumors from this high-risk geographic area in search of clues to the mutagenic processes involved in causing ESCC.<h4>Methodology/principal findings</h4>Biopsies of 119 confirmed ESCC tumor tissue from subjects enrolled in a case-control study cond ...[more]