Ontology highlight
ABSTRACT:
SUBMITTER: Yonezawa A
PROVIDER: S-EPMC3246706 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Yonezawa Atsushi A Inui Ken-ichi K
British journal of pharmacology 20111201 7
The renal organic cation transport system mediates the tubular secretion of cationic compounds including drugs, toxins and endogenous metabolites into urine. It consists of a membrane potential-dependent organic cation transporter at the basolateral membrane and an H(+) /organic cation antiporter at the brush-border membrane. In 2005, human multidrug and toxin extrusion MATE1/SLC47A1 was identified as a mammalian homologue of bacterial NorM. Thereafter, human MATE2-K/SLC47A2 and rodent MATE were ...[more]