Sodium leak channels in neuronal excitability and rhythmic behaviors.
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ABSTRACT:
SUBMITTER: Ren D
PROVIDER: S-EPMC3247702 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Publications
Sodium leak channels in neuronal excitability and rhythmic behaviors.
Neuron 20111201 6
Extracellular K⁺, Na⁺, and Ca²⁺ ions all influence the resting membrane potential of the neuron. However, the mechanisms by which extracellular Na⁺ and Ca²⁺ regulate basal neuronal excitability are not well understood. Recent findings suggest that NALCN, in association with UNC79 and UNC80, contributes a basal Na⁺ leak conductance in neurons. Mutations in Nalcn, Unc79, or Unc80 lead to severe phenotypes that include neonatal lethality and disruption in rhythmic behaviors. This review discusses t ...[more]
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