Ontology highlight
ABSTRACT:
SUBMITTER: Palacios-Rodriguez Y
PROVIDER: S-EPMC3247988 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Palacios-Rodríguez Yadira Y García-Laínez Guillermo G Sancho Mónica M Gortat Anna A Orzáez Mar M Pérez-Payá Enrique E
The Journal of biological chemistry 20111107 52
The caspase recruitment domain (CARD) is present in a large number of proteins. Initially, the CARD was recognized as part of the caspase activation machinery. CARD-CARD interactions play a role in apoptosis and are responsible for the Apaf-1-mediated activation of procaspase-9 in the apoptosome. CARD-containing proteins mediate the inflammasome-dependent activation of proinflammatory caspase-1. More recently, new roles for CARD-containing proteins have been reported in signaling pathways associ ...[more]