Ontology highlight
ABSTRACT:
SUBMITTER: Chen AC
PROVIDER: S-EPMC3248053 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Chen Andrew C H AC Manz Niklas N Tang Yongqiang Y Rangaswamy Madhavi M Almasy Laura L Kuperman Samuel S Nurnberger John J O'Connor Sean J SJ Edenberg Howard J HJ Schuckit Marc A MA Tischfield Jay J Foroud Tatiana T Bierut Laura J LJ Rohrbaugh John J Rice John P JP Goate Alison A Hesselbrock Victor V Porjesz Bernice B
Alcoholism, clinical and experimental research 20100405 6
<h4>Background</h4>Endophenotypes reflect more proximal effects of genes than diagnostic categories, hence providing a more powerful strategy in searching for genes involved in complex psychiatric disorders. There is strong evidence suggesting the P3 amplitude of the event-related potential (ERP) as an endophenotype for the risk of alcoholism and other disinhibitory disorders. Recent studies demonstrated a crucial role of corticotropin releasing hormone receptor 1 (CRHR1) in the environmental st ...[more]