Targeting the PI3K/Akt/mTOR pathway--beyond rapalogs.
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ABSTRACT:
SUBMITTER: Markman B
PROVIDER: S-EPMC3248125 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Publications
Targeting the PI3K/Akt/mTOR pathway--beyond rapalogs.
Markman Ben B Dienstmann Rodrigo R Tabernero Josep J
Oncotarget 20101101 7
It is well established that the PI3K pathway plays a central role in various cellular processes that can contribute to the malignant phenotype. Accordingly, pharmacological inhibition of key nodes in this signaling cascade has been a focus in developmental therapeutics. To date, agents targeting upstream receptor tyrosine kinases are best studied and have achieved greatest clinical success. Further downstream, despite efficacy in certain tumor types, the rapalogs have been somewhat disappointing ...[more]
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