Ontology highlight
ABSTRACT:
SUBMITTER: Kokabu S
PROVIDER: S-EPMC3248326 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Kokabu Shoichiro S Gamer Laura L Cox Karen K Lowery Jonathan J Tsuji Kunikazu K Raz Regina R Economides Aris A Katagiri Takenobu T Rosen Vicki V
Molecular endocrinology (Baltimore, Md.) 20111110 1
Enhancing bone morphogenetic protein (BMP) signaling increases bone formation in a variety of settings that target bone repair. However, the role of BMP in the maintenance of adult bone mass is not well understood. Targeted disruption of BMP3 in mice results in increased trabecular bone formation, whereas transgenic overexpression of BMP3 in skeletal cells leads to spontaneous fracture, consistent with BMP3 having a negative role in bone mass regulation. Here we investigate the importance of BMP ...[more]