Ontology highlight
ABSTRACT:
SUBMITTER: Zhang W
PROVIDER: S-EPMC3248469 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Zhang Wei W Thompson Barry J BJ Hietakangas Ville V Cohen Stephen M SM
PLoS genetics 20111229 12
The insulin/IGF-activated AKT signaling pathway plays a crucial role in regulating tissue growth and metabolism in multicellular animals. Although core components of the pathway are well defined, less is known about mechanisms that adjust the sensitivity of the pathway to extracellular stimuli. In humans, disturbance in insulin sensitivity leads to impaired clearance of glucose from the blood stream, which is a hallmark of diabetes. Here we present the results of a genetic screen in Drosophila d ...[more]