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Protein dynamical transition at 110 K.

ABSTRACT: Proteins are known to undergo a dynamical transition at around 200 K but the underlying mechanism, physical origin, and relationship to water are controversial. Here we report an observation of a protein dynamical transition as low as 110 K. This unexpected protein dynamical transition precisely correlated with the cryogenic phase transition of water from a high-density amorphous to a low-density amorphous state. The results suggest that the cryogenic protein dynamical transition might be directly related to the two liquid forms of water proposed at cryogenic temperatures.

SUBMITTER: Kim CU

PROVIDER: S-EPMC3248492 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature

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Protein dynamical transition at 110 K.

Kim Chae Un CU Tate Mark W MW Gruner Sol M SM

Proceedings of the National Academy of Sciences of the United States of America 20111213 52

Proteins are known to undergo a dynamical transition at around 200 K but the underlying mechanism, physical origin, and relationship to water are controversial. Here we report an observation of a protein dynamical transition as low as 110 K. This unexpected protein dynamical transition precisely correlated with the cryogenic phase transition of water from a high-density amorphous to a low-density amorphous state. The results suggest that the cryogenic protein dynamical transition might be direct ...[more]

PMID: 22167801

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