Ontology highlight
ABSTRACT:
SUBMITTER: Charles JP
PROVIDER: S-EPMC3248530 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Charles Jean-Philippe JP Iwema Thomas T Epa V Chandana VC Takaki Keiko K Rynes Jan J Jindra Marek M
Proceedings of the National Academy of Sciences of the United States of America 20111213 52
Juvenile hormone (JH) is a sesquiterpenoid of vital importance for insect development, yet the molecular basis of JH signaling remains obscure, mainly because a bona fide JH receptor has not been identified. Mounting evidence points to the basic helix-loop-helix (bHLH)/Per-Arnt-Sim (PAS) domain protein Methoprene-tolerant (Met) as the best JH receptor candidate. However, details of how Met transduces the hormonal signal are missing. Here, we demonstrate that Met specifically binds JH III and its ...[more]