A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.
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ABSTRACT:
SUBMITTER: Kemp MM
PROVIDER: S-EPMC3248787 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.
Kemp Melissa M MM Wang Qiu Q Fuller Jason H JH West Nathan N Martinez Nicole M NM Morse Elizabeth M EM Weïwer Michel M Schreiber Stuart L SL Bradner James E JE Koehler Angela N AN
Bioorganic & medicinal chemistry letters 20110602 14
Histone deacetylases (HDACs) are enzymes involved in many important biological functions. They have been linked to a variety of cancers, psychiatric disorders, and other diseases. Since small molecules can serve as probes to study the relevant biological roles of HDACs, novel scaffolds are necessary to develop more efficient, selective drug candidates. Screening libraries of molecules may yield structurally diverse probes that bind these enzymes and modulate their functions in cells. Here we rep ...[more]
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