Ontology highlight
ABSTRACT:
SUBMITTER: Chu J
PROVIDER: S-EPMC3248904 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Chu Jaime J Loughlin Elizabeth A EA Gaur Naseem A NA SenBanerjee Sucharita S Jacob Vinitha V Monson Christopher C Kent Brandon B Oranu Amanke A Ding Yuanying Y Ukomadu Chinweike C Sadler Kirsten C KC
Molecular biology of the cell 20111109 1
Ubiquitin-like, containing PHD and RING finger domains 1 (uhrf1) is regulated at the transcriptional level during the cell cycle and in developing zebrafish embryos. We identify phosphorylation as a novel means of regulating UHRF1 and demonstrate that Uhrf1 phosphorylation is required for gastrulation in zebrafish. Human UHRF1 contains a conserved cyclin-dependent kinase 2 (CDK2) phosphorylation site at Ser-661 that is phosphorylated in vitro by CDK2 partnered with cyclin A2 (CCNA2), but not cyc ...[more]