Divergent evolution in enolase superfamily: strategies for assigning functions.
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ABSTRACT:
SUBMITTER: Gerlt JA
PROVIDER: S-EPMC3249080 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Publications
Divergent evolution in enolase superfamily: strategies for assigning functions.
Gerlt John A JA Babbitt Patricia C PC Jacobson Matthew P MP Almo Steven C SC
The Journal of biological chemistry 20111108 1
Nature's strategies for evolving catalytic functions can be deciphered from the information contained in the rapidly expanding protein sequence databases. However, the functions of many proteins in the protein sequence and structure databases are either uncertain (too divergent to assign function based on homology) or unknown (no homologs), thereby limiting the utility of the databases. The mechanistically diverse enolase superfamily is a paradigm for understanding the structural bases for evolu ...[more]
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